Why use a toothpaste with nano medical hydroxyapatite?
It supports saliva’s natural restorative role. Enamel is made of tightly packed hydroxyapatite rods separated by ~50 nm channels; demineralization dissolves these rods, and saliva normally supplies calcium and phosphate to rebuild them. When biofilm is excessive, saliva is inadequate, or acidic intake is high, extra mineral is needed. Nano medical hydroxyapatite supplements salivary mineral and reverses incipient caries and white spot lesions.
Is X-PUR Remin good for dry-mouth (xerostomic) patients?
Yes. Dry-mouth patients lose saliva’s restorative role, tipping the balance toward demineralization and faster plaque-driven decay. Because Remin supplies hydroxyapatite directly, it helps compensate for the missing salivary mineral.
How deep into the enamel/dentin does it penetrate?
One in-vitro study on extracted teeth showed the medical hydroxyapatite penetrated near the dentin-enamel junction, about 500 microns from the enamel surface.
How does it target cariogenic bacteria without removing beneficial bacteria?
Hydroxyapatite strongly binds proteins, including bacteria, and binds especially to gram-positive cariogenic bacteria such as Streptococcus mutans, which colonize the tooth surface (not saliva or mucosa). When teeth are brushed with hydroxyapatite toothpaste, these bacteria attach to the hydroxyapatite and are removed on rinsing.
Is X-PUR Remin safe for people with dairy allergies?
Yes. Its ingredients are not dairy-derived; the calcium comes from a natural geological (mined) source, not animal sources.
What is sodium-N-lauroyl-L-glutamate?
A sodium salt made from glutamic acid and lauric acid. It provides moderate detergency and foaming, is biodegradable, and its mild acidity makes it very gentle.
What is used for flavour?
A mixture of natural and synthetic ingredients, mostly plant-derived.
What is beta-glycyrrhetinic acid?
An ingredient made from liquorice root, used to help reduce and prevent gum disease.
Is the nano hydroxyapatite a form of calcium?
Yes. It is a crystalline form of calcium phosphate, the same substance as our bones and teeth.
How do X-PUR Remin and fluoride work together?
The main action of fluoride is topical: while fluoride is available in the mouth, remineralization can occur. Remin adds an indirect action through its mineral, which conducts to medical hydroxyapatite binding, giving a mixed remineralizing effect that is helpful for high-caries-risk patients.
How can Remin remineralize without saliva when fluoride needs it?
Fluoride requires saliva as a delivery vehicle plus bioavailable calcium and phosphate, and becomes less effective below a certain pH. Medical nano hydroxyapatite does not require saliva: it works through electrostatic interaction between the negatively charged enamel and the positively charged hydroxyapatite nanoparticles in an acidic environment. Being already in the tooth’s mineral form, it biologically bonds with tooth structure to repair micro-fissures and remineralize. It is pH-neutral, non-toxic, and safe for all ages.
Are the nanoparticles safe?
Yes. There is no evidence that nano-hydroxyapatite enters the body or bloodstream through oral soft tissue during brushing. In-vitro tests on 3D reconstituted oral epithelium show nanoparticles do not penetrate beyond the most superficial cell layer, which is naturally shed roughly every 5 days, and even then only in minute amounts.
Is nanoXIM by FLUIDINOVA the only globally recognized and approved nano-hydroxyapatite?
No, that claim is misleading. Under the EU’s revised Cosmetic Products Regulation (Commission Regulation (EU) 2024/858), nano-hydroxyapatite meeting the Annex III specifications is approved as safe in cosmetic toothpastes up to 10%, regardless of manufacturer. Although Fluidinova supplied much of the safety data, the assessment applies to all conforming nano-HAP. SANGI’s ingredient fully meets these criteria. Nano-HAP is also widely used safely in medicine (implant coatings, bone grafts, dermal fillers) and has decades of safe use.
How is the manufacturer addressing pressure to move away from titanium dioxide?
Almost none of their toothpastes contain titanium dioxide. The only one that did, a kids’ toothpaste, was reformulated without it over a year ago in response to EU public sentiment, despite titanium dioxide being recognized as safe in toothpaste in Japan and Canada. The manufacturer maintains it is safe but removed it in response to market and regulatory pressure, and is evaluating future alternatives.