A NASA-born calcium phosphate compound, refined and patented by Sangi Co. — selected by Oral Science for X-PUR Remin, a Health Canada–indicated fluoride-free toothpaste that helps reduce caries.
Identical to the calcium phosphate compound that builds teeth — biocompatible by design, safe and naturally absorbed.
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Born at NASA
1970 origin · patent acquired by Sangi 1978
Engineered to restore astronaut bone and tooth loss in zero-gravity, refined by Sangi into the world’s first enamel-restorative toothpaste.
From Space to Smiles
A Crystal Engineered to Rebuild Enamel
Hydroxyapatite — Ca₁₀(PO₄)₆(OH)₂ — is the calcium phosphate crystal that makes teeth tough. In nano-medical form (50 nm), it slips below the enamel surface to deliver replacement calcium and phosphate ions exactly where minerals have been lost.
50 nm CrystalsCa₁₀(PO₄)₆(OH)₂
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Rebuilds Enamel
Below the surface · from the inside out
How Hydroxyapatite Works
Nano particles (50 nm) penetrate below the enamel surface — too small to be blocked, large enough to deposit.
Delivers replacement calcium and phosphate ions to demineralized areas, restoring enamel integrity from within.
Fills and repairs minute surface defects, returning enamel to its original smoothness and translucent gloss.
Adheres to bacteria and biofilm — helping remove them rather than chemically killing them.
Hydroxyapatite in Action
1. Penetrates Below Surface
50 nm particles slip past the outer enamel into demineralized zones.
Where saliva and fluoride can’t reach.
2. Replaces Lost Minerals
Delivers Ca²⁺ and PO₄³⁻ ions exactly where they’ve been lost.
Direct remineralization — not promoted by saliva, performed by the molecule itself.
3. Restores Integrity
Fills surface defects, removes white spots, and returns enamel to its translucent gloss.
A fluoride-free path to enamel restoration.
The Science
The Mechanism in Detail
Three distinct ways nano medical hydroxyapatite restores enamel — visualised. Backed by Sangi’s 35+ years of clinical research.
Remineralization & Reparation
Remineralization comparable to fluoride toothpaste — inhibits caries development.
Remineralizes enamel more effectively than saliva, as effectively as fluoride compounds.
Fills and repairs minute surface defects, restoring original smoothness.
Adheres to and helps remove bacteria and biofilm — protects against decay.
Removes white spots and incipient caries; restores enamel toward its original form.
Protects against biofilm attachment and stains by reducing harbouring crevices.
Tooth Sensitivity
Coats and fills exposed dentin and dentinal tubules to protect against dentin hypersensitivity — relief that comes from physical occlusion, not chemical numbing.
Whiteness & Gloss
Improves tooth whiteness and gloss — correlating with an increase in surface minerals and smoothness. A non-abrasive, all-natural approach.
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Antimicrobial Properties
Absorbs periodontal and opportunistic pathogens such as P. gingivalis and C. albicans — helping reduce oral soft-tissue infection risk.
Shows superior bacterial absorption compared with other forms of hydroxyapatite.
Shows strong selectivity for cariogenic S. mutans.
History of medical hydroxyapatite toothpastes
1970:
First synthetic form of hydroxyapatite created by NASA to help restore teeth and bone loss by astronauts following gravity-free environment missions.
1978:
Sangi Co., Ltd. acquires the patent from NASA and conceives the idea of an enamel-restorative toothpaste using the same substance as the tooth structure (hydroxyapatite).
1980:
Sangi launches the world’s first enamel-restorative toothpaste in Japan.
1985:
Studies from Tokyo Medical and Dental University (1 year / 1,026 children) and Asahi University (3 years / 181 children)
1993:
The Japanese government approves Sangi Co. Ltd.’s proprietary medical hydroxyapatite as an active anti-caries agent.
2003:
Sangi increases the enamel-restorative capabilities of medical hydroxyapatite by reducing its nanoparticles from 100 to 50 nanometers (1 nanometer = 1 millionth of a millimeter), making it more effective at penetrating below the surface of the enamel.
2013:
100 million medical hydroxyapatite toothpastes sold by Sangi over the last 35 years.
Nano medical hydroxyapatite is now the gold standard in Japan to fight cavities.
2015:
X-PUR Remin is granted the Health Canada indication of a fluoride-free toothpaste that helps reduce caries.
2024:
Nano medical hydroxyapatite is inducted into the Space Technology Hall of Fame — recognising its journey from NASA spaceflight research to a globally adopted dental innovation.
Key Benefits
Why Clinicians Choose Nano-mHAP
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Remineralizes Enamel
As effective as fluoride. Acts directly — not via saliva.
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Anti-Biofilm
Adheres to bacteria like S. mutans and P. gingivalis — and helps remove them.
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Restores Gloss
Fills minute defects, removes white spots, returns smoothness.
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Fluoride-Free
Health Canada–indicated alternative for fluoride-averse patients.
Why It Matters for Patients
An evidence-based path to restore enamel and reduce caries — backed by 35 years of clinical use and 100 million tubes sold.
Daily Patient Experience
A safe, biocompatible material — identical to your enamel.
Visible improvements: smoother teeth, fewer white spots, restored gloss.
Comfortable for sensitivity-prone and fluoride-averse patients.
