PERIOSTAT (Doxycycline Hyclate) is used in adults with gum disease (periodontitis) after a certain dental procedure (scaling and root planing). It helps to improve tooth attachment and reduce gum pockets.
PERIOSTAT contains an antibacterial ingredient called doxycycline that is also used to treat bacterial infections.
PERIOSTAT belongs to the class of antibiotics known as tetracyclines. It may help to prevent the breakdown of gum tissue. PERIOSTAT® capsule contains doxycycline hyclate which is a semi-synthetic tetracycline. Doxycycline is an inhibitor of collagenase activity.
Medicinal ingredients: Doxycycline hyclate
Non-medicinal ingredients: hard gelatin capsules, magnesium stearate, microcrystalline cellulose and titanium dioxide.
Capsules; 20 mg
PERIOSTAT can cause your skin to become sensitive to the sun. While taking PERIOSTAT, use sunscreen and protective clothing if you are going to be in direct sunlight and avoid tanning beds and other sources of UV light. If you notice any skin redness after being in the sun while taking PERIOSTAT contact your healthcare professional immediately.Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines. The following may interact with PERIOSTAT:
What are possible side effects from using PERIOSTAT? These are not all the possible side effects you may feel when taking PERIOSTAT. If you experience any side effects not listed here, contact your healthcare professional.Storage:
Side effects may include:
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
- Common cold (runny nose, sneezing, cough, sore throat)
- Flu symptoms (fever, body aches, headache, cough, sore throat)
- Sinus infection (sinusitis), sinus congestion, sinus headache
- Tooth ache or other tooth problem
- Gum pain
- Nausea, indigestion
- Joint pain, back pain/ache, muscle pain
- Menstrual cramps
Adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.
PERIOSTAT® capsule contains doxycycline hyclate which is a semi-synthetic tetracycline. Doxycycline is an inhibitor of collagenase activity. Studies have shown that low-dose doxycycline reduces the elevated collagenase activity in the gingival crevicular fluid of patients with chronic adult periodontitis, in an action unrelated to its antibacterial mode of action.
Periostat® is available as a 20 mg tablet formulation of doxycycline for oral administration.
Medicinal Ingredient: 20 mg doxycycline
Non-Medicinal Ingredients: Hard Gelatin Capsules, Magnesium Stearate, Microcrystalline Cellulose and Titanium Dioxide.
This drug is contraindicated in persons who have shown hypersensitivity to doxycycline or any of the other tetracyclines.
In a randomized, multi-centered, double-blind, 9-month Phase 3 study involving 190 adult patients with periodontal disease [at least two probing sites per quadrant of between 5 and 9 mm pocket depth (PD) and attachment level (ALv)], the effects of oral administration of 20 mg twice a day of doxycycline hyclate (using a bioequivalent capsule formulation) plus scaling and root planing (SRP) were compared to placebo control plus SRP. Both treatment groups were administered a course of scaling and root planing in 2 quadrants at Baseline. Measurements of ALv, PD and bleeding-on-probing (BOP) were obtained at Baseline, 3, 6, and 9 months from each site about each tooth in the two quadrants that received SRP using the UNC-15 manual probe. Each tooth site was categorized into one of three strata based on Baseline PD: 0-3 mm (no disease), 4-6 mm (mild/moderate disease), ≥ 7 mm (severe disease). For each stratum and treatment group, the following were calculated at month 3, 6, and 9: mean change in ALv from baseline, mean change in PD from baseline, mean percentage of tooth sites per patient exhibiting attachment loss of ≥ 2 mm from baseline, and percentage of tooth sites with bleeding on probing. The results are summarized in the following table.
Consult the full monograph here