gengigel bottle
0.2 % hyaluronic acid topical gel

The #1 treatment against oral lesions recommended by dental and medical professionals

Professionals Consumers

Mechanism of action

High molecular weight hyaluronic acid (HA) is a natural physiological constituent of connective tissue. Made up mostly of collagen, it is one of the major components of the human body. HA is the most abundant high molecular weight glycosaminoglycan of healthy soft periodontal tissues.4 It is active in tissue regeneration and influences the migration of fibroblasts and fibrinogenesis, thus making the healing of tissue easier. It performs 3 synergistic effects: anti-inflammatory, accelerates the healing process and provides a protective barrier.

Contributing to the barrier function and tensile strength of the periodontal ligament, HA is essential for healthy gingival tissues. In the initial stage of inflammation and periodontal disease, tissue’s requirement for HA increases by 200%, demonstrating its central role in regulating cell turnover and optimizing tissue regeneration. When lacking HA, healing will be delayed and inflammation will continue.


• Bacteriostatic effect
• Improves tissue regeneration process (supports natural healing process)
• Modulates effect on inflammation

3 synergistic effects of gengigel: reparative, anti-inflammatory and proctective


Helps to relieve pain and reduce gingival inflammation associated with:

  • Bleeding
  • Candida
  • Dentures
  • Dry mouth
  • Gingivitis
  • Implant uncovery
  • Lichen planus
  • Mouth sores
  • Oral lesions
  • Orthodontic braces
  • Post-surgical recovery
  • Scaling
  • Tooth extractions
  • Ulcers
  • Wounds


Medicinal Ingredients
• 0.2 % Hyaluronic acid
• 7.5 % Xylitol (extracted from birch and beech trees)

Non-Medicinal Ingredients
Water, cellulose gum, alcohol, PEG40 hydrogenated castor oil, polyvinyl alcohol, polycarbophil, 2,4 dichlorobenzyl alcohol, flavor, sodium hydroxyde, CI 42090.





Clinical uses

• Geriatrics
• Oral Lesions
• Oncology treatment
• Pediatrics
• Periodontitis
• Xerostomia

Directions for use

Adults and children 3 years and older
2 to 3 times a day after meals, for 3 to 4 weeks continuing until all symptoms have disappeared
1. Use an antibacterial toothpaste (X-PUR Remin) or oral rinse (X-PUR Opti-Rinse).
2. Apply a film of gel onto the gingival tissue, massaging gently with clean fingers to aid correct distribution on the mucosal surface.
3. Do not eat, drink or rinse for 30 minutes.


Pregnant or breastfeeding, consult a health care professional prior to use.

Gengigel vs the competition

table showing Gengigel is superior than bezocaine products

Medicinal Ingredients

High molecular weight hyaluronic acid (HA) is a natural physiological constituent of connective tissues. It is the most abundant high molecular weight glycosaminoglycan of healthy soft periodontal tissues.4

Xylitol is a 100% natural sweetener derived from vegetable sources. Twenty years of research shows xylitol efficacy treating dry mouth and reducing tooth decay.


I have had such good response to the Gengigel! Wow. I've had some nasty, big, long subling ulcers come along and I applied the gel chair side and the patients reported relief from the gel in minutes- amazing. Patients are so grateful! Yesterday I tried it on a geographic tongue that was sore with a "flare up" and same thing- sheer excitement for the patient. She's suffered with these bouts of tenderness forever, but not anymore!

- Christine, a dental hygienist from British Columbia

I randomly stumbled upon gengigel in the pharmacy when searching for a treatment for a terrible canker I had. Ive had cankers my whole life, I get them from mouth trauma (e.g. biting cheek). Anyways, Ive tried everything.. alum, baking soda, kanka, etc etc. Nothing really works. Well, gengigel has been a life saver. You may not feel it working when you initially put it on, but this stuff got rid of my canker in 2 DAYS, 2 DAYS people. Thats unheard of for me. The best part is it easy to apply (don't need to let it try), it tastes like nothing, and its NOT toxic is swallowed. I can't even believe how well it works! I apply several times a day and have seen great result. Would def purchase again.

- Penny, a patient


  1. Bansal J, Kedige SD, Anand S., Hyaluronic acid: A promising mediator for periodontal regeneration, Indian J Dent Res 2010;21:575-578. [download]
  2. Rahemtulla F., Proteoglycans of oral tissues, Crit Rev Oral Biol Med 1992;3:135-162. [download]
  3. Salazar Monsalve L, Rodríguez Lara V, González Villalva AE. En Fortoul T, Castell A., Histología y biología celular, McGrawHill México, 1ª ed. 2010. Capítulo 5: Tejidos. [link]
  4. Sukumar S, Drízhal I., Hyaluronic acid and periodontitis, Acta Medica (Hradec Kralove) 2007;50:225-258. [download]
  5. Weigel PH, Hascall VC, Tammi M., Hyaluronan Synthases, J Biol Chem 1997;272(22):13997-14000.[download]
  6. Hascall VC, Laurent TC., Hialuronan: Structure and physical properties, 1997. [link]
  7. Silvera Arenas LA, Barrios de Zurbarán C., La matriz extracelular: el ecosistema de la célula Salud Uninorte. Barranquilla 2002;16:9-18. [link]
  8. Choukroun J, Diss A, Simonpieri A et al., Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing Med Oral Pathol Oral Radiol Endod 2006; 101:E56-E60. [link]
  9. Weigel PH, Fuller GM, Le-Boeuf RD., A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing, J Theor Biol 1986;119(2):219-234. [download]
  10. Sakasi T, Watanabe C., Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid, Bone 1995;16:9-15. [link]
  11. Pirnazar P, Wolinsky L, Nachnani S et al., Bacteriostatic effects of hyaluronic acid, J Periodontol 1999;70:370-374. [link]
  12. Sakai A, Akifusa S, Itano N et al., Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells, Med Mycil Feb 2007;45(1):73-79. [download]


Consult MSDS