Oral Science Protocol

Minimally Invasive Treatment For Caries Management

Dental Caries: A Reversible Disease, A New Treatment Paradigm

A Reversible Disease, A New Treatment Paradigm

For non-cavitated lesions, the majority of enamel caries can be remineralized. Too often carious lesions are simply restored, and the lifelong cycle of replacing tooth structure with restorations begins.

This protocol combines in-office and home-care solutions to promote arrest and reversal of the caries process by tooth remineralization, and it helps to optimize the oral flora.

The caries process progresses over time through adhesion, colonization, de- and re-mineralization, white spot, enamel lesion, dentin lesion, and pulpal lesion. Early diagnosis and prevention allow clinicians to intervene before restoration becomes necessary.

High Risk Caries

When clients present with any of the following:

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Acidic & High Sugar Diet

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Compromised Medical History

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Deep Pit & Fissures

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Defective Restorations

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Familial Risks

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Lack of Fluoride Exposure

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Orthodontics

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Poor Oral Self-Care

⚠️

Recent Decay

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Recession

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Xerostomia

White Spot Lesions

In-Office Caries Management

Minimally Invasive Treatment

Non-Cavitated Lesions

Remineralize The Carious Lesions

FluoriMax — 2.5% Sodium Fluoride Varnish

  • Chalky white or light brown demineralization of enamel
  • No break in tooth structure based on tactile or visual means
  • Colophony-free (non-tacky) varnish — superior fluoride uptake, enhanced patient experience, cost effective
  • Indicated by Health Canada

Cavitated Lesions

Arrest The Carious Lesions

Advantage Arrest — 38% Silver Diamine Fluoride

  • Visual breakdown of surface integrity, loss of enamel and dentin
  • Arrests the progress of an already formed carie in permanent or primary teeth
  • Increases mineral density, hardness, and resistance to acid dissolution
  • Outperforms other anti-caries treatments in killing cariogenic bacteria
  • Non-invasive treatment option

Cavitated Lesions (OR)

Remove Carious Dentin

Papacárie Duo® — Papain | To Facilitate Tooth Restoration

  • Facilitates selective caries removal
  • Enhances atraumatic restorative treatment (ART) and silver modified atraumatic restorative treatment (SMART)
  • Gently and painlessly remove caries by spoon or slow-speed excavation
  • Improves bond strength
  • Antimicrobial

Home-Care Caries Management

Minimally Invasive Treatment

1. Transform The Cariogenic Oral Flora Into a Non-Cariogenic Flora

High Intensity Treatment

X-PUR CariØ Plus — 25% Xylitol & CITROX® Toothpaste. After meals, at least 2 times a day for a minimum of 3 months.

X-PUR Opti-Rinse Plus 0.2% — Neutral Sodium Fluoride, Xylitol, CITROX®, and Cetylpyridinium Chloride Rinse. Before bed, rinse daily for 1 month (approx. 10 mL).

2. Maintain The Non-Cariogenic Oral Flora For Caries Prevention And Remineralization

Indicated For Long-Term Use

X-PUR CariØ Plus — 25% Xylitol & CITROX® Toothpaste. After meals, at least 2 times a day for a minimum of 3 months.

X-PUR Opti-Rinse Plus — Neutral Sodium Fluoride, Xylitol, CITROX®, and Cetylpyridinium Chloride Rinse. Before bed, rinse weekly or daily (approx. 10 mL). Ongoing.

If Your Patient Presents with White Spot Lesions, Xerostomia or Tooth Sensitivity

X-PUR Remin — 10% Nano Medical Hydroxyapatite and 10% Xylitol Toothpaste. Helps to remineralize tooth enamel, reduce dentinal hypersensitivity and reduce caries. After meals, at least 2 times a day for a minimum of 3 months.

X-PUR Opti-Rinse Plus — Before bed, rinse weekly or daily (approx. 10 mL). Ongoing.

Instructions For Use

FluoriMax

Frequency of application: every 3–6 months

  • Remove excessive biofilm or calculus and shake the bottle well for 15 seconds before each application
  • Have patient swallow or suction pooled saliva, but leave teeth moist
  • Dispense immediately before application, holding the bottle completely upside down; remove excess varnish from the brush
  • Adults: 3 drops. Children: 1–2 drop(s)
  • Apply one thin continuous layer across the facial/buccal surfaces, one quadrant at a time, then allow to dry 3–5 seconds
  • Post-treatment: patient can eat and drink right away; for optimal results avoid alcohol and do not brush or floss for 4 hours

Advantage Arrest

Review consent form and inform the patient of the staining

  • Provide protective eyewear; apply vaseline to lips and surrounding tissues to avoid staining skin
  • Isolate the affected area with a cotton roll and/or dri-angle, then dry the lesion or surface
  • Dispense 1 drop into a disposable dish (1 drop treats up to 5 tooth surfaces) and apply to the lesion
  • Allow it to soak in for 60 seconds and up to 3 minutes for cooperative patients
  • Remove excess and cover the treated area with a thin layer of fluoride varnish (FluoriMax)
  • A second application within 1–2 weeks increases arrest from approx. 74% to approx. 91%; reapply every 3–6 months or place a self-curing glass ionomer restoration

Papacárie Duo®

Adults & children (2 years and older): 0.1–3 mL, 1 time per day, by a dental professional

  • Only reacts in contact with caries-damaged dentin; healthy tooth tissue is unaffected by the active ingredient
  • Apply gel to the caries-damaged tooth and allow to sit for 30–60 seconds
  • Tap area to determine if damaged dentin is soft enough to gently scoop out, and scoop out as required
  • Reapplication can be done immediately with no need to rinse or dry in between steps; repeat until all damaged dentin is removed

The Full Protocol

View the complete protocol flyer pages as published.

In-Office Caries Management

Home-Care Caries Management

Instructions For Use & Sources

Protocol Products

Products Referenced In The Protocol

FluoriMax

2.5% Sodium Fluoride Varnish

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Advantage Arrest

38% Silver Diamine Fluoride

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Papacárie Duo®

Papain Gel For Selective Caries Removal

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X-PUR CariØ Plus

25% Xylitol & CITROX® Toothpaste

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X-PUR Remin

10% Nano Medical Hydroxyapatite & 10% Xylitol Toothpaste

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X-PUR GummiZ

Medicinal-Grade Xylitol & CITROX® Gummies

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X-PUR Opti-Rinse Plus

Neutral Sodium Fluoride, Xylitol, CITROX® & CPC Rinse

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Minimally Invasive Treatment For Caries Management

This protocol is intended to serve as a general guideline and does not encompass all possible clinical scenarios. Clinicians are advised to use their professional judgment and consider individual patient circumstances when making clinical decisions.

Sources

  1. Véronneau, Jacques. (2018). Medical Treatment of Dental Caries with a new 25% Xylitol Formulation. Oral Health, pages 52–57.
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  12. Lesion arrest rates after 1 and 2 applications of 38% SDF were 74.1%–81% after the first application, and 91%–96.2% after the second application. Crystal, Y., Niederman, R. (2019). Evidence-Based Dentistry Update on Silver Diamine Fluoride. Dental Clinics of North America, Volume 63, Issue 1, pages 45–68; AND Sihra, R., Schroth, Robert J., Bertone, M., et al. (2020). The Effectiveness of Silver Diamine Fluoride and Fluoride Varnish in Arresting Caries in Young Children and Associated Oral Health-Related Quality of Life. The Journal of Canadian Dental Association, Volume 86: K9, pages 1–9.
  13. Reapply at intervals of every 3–6 months. [Reference to be confirmed]
  14. World Health Organization. (2021). Application for new medication: fluoride varnish.
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