X-PUR Opti-Rinse Plus 0,05% fluorure de sodium 1 L – Raisin

Étude

Préparé par: Dennis Cvitkovitch PhD, Professor, Faculty of Dentistry, University of Toronto. 12 septembre 2021.

X-PUR^® Opti-Rinse Plus is a preventative, non-prescription mouthrinse. It provides therapeutic benefits, and should be recognized for its potential use in-office as an effective Pre-Procedural Mouthrinse (PPMR), and recommended by today’s dental professional for oral self-care.

The Institute for Antiviral Research at Utah State University performed testing of X-PUR® Opti-Rinse Plus against the SARS-CoV-2 virus. Results confirmed that X-PUR® Opti-Rinse Plus 0.2% and X-PUR^® Opti-Rinse Plus 0.05% were both cytotoxic to SARS-CoV-2 viral cells, and exhibited viricidal activity, reducing the virus below the limit of detection after a 1-minute contact time (LRV>1.9, >90%), equivalent to a 98.74% reduction. This demonstrates the ability of X-PUR^® Opti-Rinse Plus to work as an effective PPMR.

Further research conducted at the Faculty of Dentistry at the University of Toronto with X-PUR^® Opti-Rinse Plus 0.2% and the X-PUR^® Opti-Rinse Plus 0.05% compared favorably to a prescription rinse containing .12% chlorhexidine for their ability to kill and/or inhibit several oral pathogens, including:

• Porphyromonas gingivalis, a proteolytic anaerobe associated with periodontal disease, that mainly affects adults by causing destruction of alveolar bone resulting in eventual tooth loss. This bacterium has also been shown to colonize distal organs including the heart^1,2 and brain³, potentially causing systemic disorders including heart and Alzheimer’s disease
• Streptococcus mutans, the most common bacteria associated with the initiation of caries, predominant in childhood caries⁴
• Streptococcus sobrinus, an additional risk factor exacerbating caries activity⁴
• Lactobacillus casei, predominant in childhood caries⁶
• Candida albicans, positively associated with early childhood caries^6,7, a comorbidity of hyposalivation⁸, predominant in long-term care residents with prostheses, and a risk factor for pneumonia⁹

After exposure to the full strength rinses for one minute, all three rinses demonstrated: a 3-log reduction (i.e. 99.9% killing) was detected against P. gingivalis; in C. albicans, there was at least a 4 log reduction (>99.99% killing); L. casei was killed with >99.999% efficiency; S. mutans showed at least 99% of the tested cells were killed; for S. sobrinus, no colonies were detected with any of the rinses for the exposure time detected (>99.999% killing).

In the natural environment of dental plaque, bacteria grow as a biofilm attached to the tooth surface. When the three rinses were tested against biofilm-grown cells, the most prominent effect was observed with P. gingivalis and X-PUR^® Opti-Rinse Plus 0.2% treatment, with a 50% reduction in biofilm biomass after 10 minutes of exposure. With X-PUR^® Opti-Rinse Plus 0.05%, there was a 40% reduction in biofilms, while the chlorhexidine rinse was only able to reduce biofilms by 10%.

X-PUR^® Opti-Rinse Plus (0.05% & 0.2%) are proven mouth rinses for optimal outcomes.