perichlor bottle

Chlorhexidine gluconate oral rinse

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Most widely recommended treatment for gigivitis with 65% less alcohol than the leading brand*

Mechanism of action

The efficacy of chlorhexidine begins when its positively charged molecule is attracted to the negatively charged phospholipids in the cell wall (bacteria). This interferes with the enzymes found on the cell wall. These enzymes are responsible for controlling the flow of nutrients and waste products that pass through the cell wall, activities necessary for cell life. The inhibition of these enzymes causes the cell walls to become more permeable. This increase in permeability allows materials outside the cell wall, including chlorhexidine, to seep into the cells. At the same time, life-­sustaining molecules in the cytoplasm seep out through the cell wall. Cytoplasm is the gel like matrix of a cell outside the nucleus where much of the cell metabolism occurs. This seeping out process inhibits the repair of the cell wall, resulting in the death of the bacteria.

Benefits

• Antimicrobial and antifungal properties
• Only 4 % alcohol (65 % less alcohol than the leading brand)* • Sweetened with 10 % xylitol for a great taste

Indications

For use as part of a professional program for:
• The management of associated gingival bleeding and inflammation between dental visits
• The treatment of moderate to severe gingivitis

Active Ingredient

0.12 % Chlorhexidine

DIN

02240433

Directions for use

Adults
Twice daily
Rinse mouth with 15ml of undiluted solution for 30 seconds (after breakfast and before bedtime), and expectorate, or use as prescribed by a dentist.

Warnings

Most Serious :
Breastfeeding : It is not known whether or not this drug is excreted in breast milk.
Pediatrics : Since the safety and efficacy of Perichlor in children has not yet been fully established, the benefits of its use should be weighed against the possible risks.
Pregnant women : Since controlled studies in pregnant women have not been conducted, the benefits of use of the drug in pregnant women should be weighed against possible risk to the fetus.
Staining of dental surfaces : May cause some tooth discoloration or increases in tartar (calculus) formation, particularly in areas where plaque is more difficult to remove with normal brushing alone. It is important to do a thorough job of cleaning your teeth and to see a dentist at least every six months, or more frequently if prescribed. Both stains and tartar can be removed by a dentist or hygienist. Do not swallow.
Taste alteration

Contraindication :
Perichlor should not be used by persons who are known to be hypersensitive to chlorhexidine gluconate or other formula ingredients.

Consult the product monograph*** for important information relating to adverse reactions, drug interactions and dosing information which have not been discussed in this piece.

References

*3M Peridex contains 11.6% alcohol.
**Comparative clinical significance has not been established.
***Health Canada Drug Products Database